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Article

The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses.

Genetics - 1 Dec 2015

Caballero Armando, Tenesa Albert, Keightley Peter D

Abstract excerpt

We use computer simulations to investigate the amount of genetic variation for complex traits that can be revealed by single-SNP genome-wide association studies (GWAS) or regional heritability mapping (RHM) analyses based on full genome sequence data or SNP chips. We model a large population subject to mutation, recombination, selection, and drift, assuming a pleiotropic model of mutations sampled from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

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Identifiers

PMID: 26482794
DOI: 10.1534/genetics.115.177220
PMCID: PMC4676519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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