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Article

Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

5 May 2022

Abstract excerpt

Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that encodes for Polycystin-1. How loss of Polycystin-1 translates into bilateral renal cyst development is mostly unknown. cAMP is significantly involved in cyst enlargement but its role in cyst initiation has remained elusive. Deletion of...

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PMID: 35620436
DOI: 10.1016/j.isci.2022.104359

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