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PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids

3 Aug 2020

Abstract excerpt

Significance Statement Models of autosomal dominant polycystic kidney disease (ADPKD) are possible in nephron progenitor–derived human kidney organoids that form from induced pluripotent stem cells (iPSCs) that have had PKD genes deleted, enabling cyst formation. However, this has not been achieved in the ureteric bud/collecting duct lineage, despite the prevalence of collecting duct cysts in patients. Cysts...

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PMID: 32747355
DOI: 10.1681/asn.2020030378

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