Article
The genetics and physiology of polycystic kidney disease.
Seminars in nephrology - 1 Mar 2001
Calvet J P, Grantham J J
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of affected kidneys, and by a number of extrarenal manifestations including liver and pancreatic cysts, hypertension, heart valve defects, and cerebral and aortic aneurysms. Mutations in either of 2 different genes (PKD1 or PKD2)...
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