Article
Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.
Kidney international - 1 May 2014
Fonseca Jonathan M, Bastos Ana P, Amaral Andressa G, Sousa Mauri F, Souza Leandro E, Malheiros Denise M, Piontek Klaus, Irigoyen Maria C, Watnick Terry J, Onuchic Luiz F
Abstract excerpt
We have bred a Pkd1 floxed allele with a nestin-Cre expressing line to generate cystic mice with preserved glomerular filtration rate to address the pathogenesis of complex autosomal dominant polycystic kidney disease (ADPKD) phenotypes. Hypertension affects about 60% of these patients before loss of renal function, leading to significant morbimortality. Cystic mice were hypertensive at 5 and 13 weeks of age, a...
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