Article
Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells.
Kidney international - 1 Aug 2001
Sutters M, Yamaguchi T, Maser R L, Magenheimer B S, St John P L, Abrahamson D R, Grantham J J, Calvet J P
Abstract excerpt
BACKGROUND: Polycystic kidney disease (PKD) is characterized by the abnormal proliferation of tubular epithelial cells. It was recently shown that the growth of PKD cyst-lining cells is stimulated by cyclic adenosine monophosphate (cAMP), whereas the growth of normal human kidney cortex cells is inhibited. METHODS: We have examined the effects of overexpressing the C-terminal cytosolic tail of mouse polycystin-1,...
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