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Article

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

28 Nov 2007

Abstract excerpt

BACKGROUND: Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene account for a significant proportion of autosomal-dominant and some late-onset sporadic Parkinson's disease. Elucidation of LRRK2 protein function in health and disease provides an opportunity for deciphering molecular pathways important in neurodegeneration. In mammals, LRRK1 and LRRK2 protein comprise a unique family encoding a GTPase...

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PMID: 18045479
DOI: 10.1186/1471-2202-8-102

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