Article

Preclinical Modeling of Chronic Inhibition of the Parkinson’s Disease Associated Kinase LRRK2 Reveals Altered Function of the Endolysosomal System in Vivo

2020-09-25

Abstract excerpt

<title>Abstract</title> <p>BackgroundThe most common mutation in the<italic> Leucine-rich repeat kinase 2</italic> gene (LRRK2), G2019S, causes familial Parkinson’s Disease (PD) and renders the encoded protein kinase hyperactive. To date, the molecular effects of chronic LRRK2 inhibition have not yet been examined <italic>in vivo</italic>. MethodsWe evaluated the utility of newly available phospho-antibodies for...

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Literature Corpus work: be7c789c-809b-52d7-a5ed-3f24d3afbb83
DOI: 10.21203/rs.3.rs-78203/v1

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