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Article

Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2009

Scaloni Flavio, Gianni Stefano, Federici Luca, Falini Brunangelo, Brunori Maurizio

Abstract excerpt

Nucleophosmin (NPM1) is a ubiquitously expressed protein and is one of the most abundant proteins found in the nucleolus. Naturally occurring mutations in the C-terminal domain of nucleophosmin (Cter-NPM1) are found in approximately 30% of patients with acute myeloid leukemia (AML). These mutatio...

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Source

Identifiers

PMID: 19289604
DOI: 10.1096/fj.08-128306

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19289604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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