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Article

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Circulation research - 21 Jun 2024

Jiang Jiahao, Hiron Thomas K, Agbaedeng Thomas A, Malhotra Yashaswat, Drydale Edward, Bancroft James, Ng Esther, Reschen Michael E, Davison Lucy J, O'Callaghan Chris A

Abstract excerpt

BACKGROUND: Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specific causal variants and their regulatory mechanisms are still largely unknown, particularly in disease-relevant cell types such as macrophages. METHODS: We utilized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38747151
DOI: 10.1161/CIRCRESAHA.123.324172
PMCID: PMC11191562

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