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Article

Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies.

Blood - 8 Apr 2010

O'Keefe Christine, McDevitt Michael A, Maciejewski Jaroslaw P

Abstract excerpt

Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a powerful karyotyping tool in numerous translational cancer studies. SNP-A complements traditional metaphase cytogenetics with the unique ability to delineate a previously hidden chromosomal defect, copy neutral loss of heterozygosity (CN-LOH). Emerging data demonstrate that selected hematologic malignancies exhibit abundant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20107230
DOI: 10.1182/blood-2009-10-201848
PMCID: PMC2854422

Genes

CBL
FLT3
JAK2
KIT
MPL
TET2

Provenance

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