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Article

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms.

Blood - 18 Jun 2009

Jankowska Anna M, Szpurka Hadrian, Tiu Ramon V, Makishima Hideki, Afable Manuel, Huh Jungwon, O'Keefe Christine L, Ganetzky Rebecca, McDevitt Michael A, Maciejewski Jaroslaw P

Abstract excerpt

Chromosomal abnormalities are frequent in myeloid malignancies, but in most cases of myelodysplasia (MDS) and myeloproliferative neoplasms (MPN), underlying pathogenic molecular lesions are unknown. We identified recurrent areas of somatic copy number-neutral loss of heterozygosity (LOH) and deletions of chromosome 4q24 in a large cohort of patients with myeloid malignancies including MDS and related mixed...

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Source

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Identifiers

PMID: 19372255
DOI: 10.1182/blood-2009-02-205690
PMCID: PMC2710933

Genes

TET2

Provenance

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Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms.PMID 19372255Read ↗

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