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Article

Clustered 8-Oxo-Guanine Mutations and Oncogenic Gene Fusions in Microsatellite-Unstable Colorectal Cancer.

JCO precision oncology - 1 May 2022

Madison Russell W, Hu Xiaoju, Ramanan Vivek, Xu Zhuxuan, Huang Richard S P, Sokol Ethan S, Frampton Garrett M, Schrock Alexa B, Ali Siraj M, Ganesan Shridar, De Subhajyoti

Abstract excerpt

PURPOSE: Colorectal carcinomas (CRCs) with microsatellite-instability (MSI) are enriched for oncogenic kinase fusions (KFs), including NTRK1, RET, and BRAF, but the mechanism underlying this finding is unclear. METHODS: The genomic profiles of 32,218 advanced CRC tumor specimens were analyzed to assess the fusion breakpoints of oncogenic alterations including KFs in microsatellite-stable and...

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Identifiers

PMID: 35584350
DOI: 10.1200/PO.21.00477
PMCID: PMC9200390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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