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The intratumor microbiome is associated with microsatellite instability

16 May 2023

Abstract excerpt

Intratumoral microbes may have multifunctional roles in carcinogenesis. Microsatellite instability (MSI) is associated with higher tumor immunity and mutational burden. Using whole transcriptome and whole genome sequencing microbial abundance data, we investigated associations of intratumoral microbes with MSI, survival, and MSI-relevant tumor molecular characteristics across multiple cancer types including...

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PMID: 37192013
DOI: 10.1093/jnci/djad083

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