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Article

NTRK fusion positive colorectal cancer is a unique subset of CRC with high TMB and microsatellite instability.

Cancer medicine - 1 Jul 2022

Wang Hui, Li Zhi-Wei, Ou Qiuxiang, Wu Xue, Nagasaka Misako, Shao Yang, Ou Sai-Hong Ignatius, Yang Yu

Abstract excerpt

TRK fusions are rare but targetable mutations which occur across a wide variety of cancer types. We report the prevalence of approximately 0.7% for NTRK-positive colorectal cancer (CRC) by genetically profiling 2519 colonic and rectal tumors. The aberrations of APC and TP53 frequently co-occurred with NTRK gene fusions, whereas RAS/BRAF oncogenic alterations and NTRK fusions were almost always mutually exclusive....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35506567
DOI: 10.1002/cam4.4561
PMCID: PMC9249987

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