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Article

Molecular Lineages of Sporadic Mismatch Repair-Deficient Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 17 Jul 2026

Foote Michael B, Harada Guilherme, Abdelfattah Somer, Urganci Nil, Manca Paolo, Shia Jinru, Walch Henry, Argilés Guillem, Artz Oliver, Yaeger Rona, Nusrat Maliha, Patel Shrey, Johannet Paul, Harrold Emily C, Rousseau Benoit, Stadler Zsofia, Wilde Callahan, Jayaprakasam Vetri Sudar, Cremolini Chiara, Lonardi Sara, Cercek Andrea, Saltz Leonard, Vakiani Efsevia, Pietrantonio Filippo, Janjigian Yelena, Schultz Nikolaus, Drilon Alex, Diaz Luis A

Abstract excerpt

PURPOSE: Mismatch repair-deficient (MMRd) colorectal cancers are classified based on MMR protein loss and BRAFV600E mutations. BRAF wild-type sporadic MMRd tumors exhibit a diverse landscape of alternative oncogenes, including gene fusions, with unclear biological and clinical significance. We evaluated mutually exclusive subtypes of sporadic MMRd tumors defined by oncogenic mitogen-activated protein kinase...

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Aged
Biomarkers, Tumor
Colorectal Neoplasms
DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins, Fusion

Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 42013404
DOI: 10.1158/1078-0432.CCR-26-0024

Genes

BRAF
EGFR
IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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