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Article

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.

Cell reports - 13 Sept 2016

Wang Ling-Yu, Hung Chiu-Lien, Chen Yun-Ru, Yang Joy C, Wang Junjian, Campbell Mel, Izumiya Yoshihiro, Chen Hong-Wu, Wang Wen-Ching, Ann David K, Kung Hsing-Jien

Abstract excerpt

The histone lysine demethylase KDM4A/JMJD2A has been implicated in prostate carcinogenesis through its role in transcriptional regulation. Here, we describe KDM4A as a E2F1 coactivator and demonstrate a functional role for the E2F1-KDM4A complex in the control of tumor metabolism. KDM4A associates with E2F1 on target gene promoters and enhances E2F1 chromatin binding and transcriptional activity, thereby...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27626669
DOI: 10.1016/j.celrep.2016.08.018
PMCID: PMC5024724

Genes

PDK1
PDK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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