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Article

Intermediate alleles of HTT: A new pathway in longevity.

Journal of the neurological sciences - 15 Jul 2022

Ingannato Assunta, Bagnoli Silvia, Bessi Valentina, Ferrari Camilla, Mazzeo Salvatore, Sorbi Sandro, Nacmias Benedetta

Abstract excerpt

Centenarians are the best example of successful aging, reaching extreme longevity escaping age-related diseases. Genome sequencing studies provided evidence for genetic factors linked to heathy long life, including genes related to age-dependent diseases. HTT (Huntingtin) gene is linked to Huntington's Disease, but also associated to longevity in capuchins and mice. HTT Intermediate alleles (IAs) are defined as...

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PMID: 35580427
DOI: 10.1016/j.jns.2022.120274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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