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Article

Huntingtin gene intermediate alleles influence the progression from subjective cognitive decline to mild cognitive impairment: A 14-year follow-up study.

European journal of neurology - 1 Jun 2022

Mazzeo Salvatore, Emiliani Filippo, Bagnoli Silvia, Padiglioni Sonia, Conti Vittoria, Ingannato Assunta, Giacomucci Giulia, Balestrini Juri, Ferrari Camilla, Sorbi Sandro, Nacmias Benedetta, Bessi Valentina

Abstract excerpt

BACKGROUND AND PURPOSE: Huntingtin (HTT) is a gene containing a key region of CAG repeats. HTT alleles containing from 27 to 35 CAG repeats are termed intermediate alleles (IAs). We aimed to assess the effect of IAs on progression of cognitive impairment in patients with subjective cognitive decline (SCD). METHODS: We included 106 patients with SCD. All the patients underwent neuropsychological assessments and...

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PMID: 35181957
DOI: 10.1111/ene.15291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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