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Article

Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol.

Frontiers in immunology - 1 Jan 2022

Ochoa Rodrigo, Lunardelli Victoria Alves Santos, Rosa Daniela Santoro, Laio Alessandro, Cossio Pilar

Abstract excerpt

Epitopes that bind simultaneously to all human alleles of Major Histocompatibility Complex class II (MHC II) are considered one of the key factors for the development of improved vaccines and cancer immunotherapies. To engineer MHC II multiple-allele binders, we developed a protocol called PanMHC-PARCE, based on the unsupervised optimization of the epitope sequence by single-point mutations, parallel...

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Identifiers

PMID: 35572587
DOI: 10.3389/fimmu.2022.862851
PMCID: PMC9094701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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