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Article

High-throughput engineering and analysis of peptide binding to class II MHC.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010

Jiang Wei, Boder Eric T

Abstract excerpt

Class II major histocompatibility complex (MHC-II) proteins govern stimulation of adaptive immunity by presenting antigenic peptides to CD4+ T lymphocytes. Many allelic variants of MHC-II exist with implications in peptide presentation and immunity; thus, high-throughput experimental tools for rapid and quantitative analysis of peptide binding to MHC-II are needed. Here, we present an expression system wherein...

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Identifiers

PMID: 20622157
DOI: 10.1073/pnas.1006344107
PMCID: PMC2922119

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Source receipt: pubmed, retrieved 7 Sept 2026.

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