Back to search

Article

Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in <i>Plasmodium falciparum</i>

2025-07-18

Abstract excerpt

Developing a highly effective malaria vaccine remains challenging due to Plasmodium falciparum ’s antigenic diversity and human leukocyte antigen (HLA) polymorphisms, which complicate vaccine antigen selection and limit immune protection. The first recommended malaria vaccine, RTS,S, provides only partial, allele-specific protection with waning immunity over time, and the more recently developed R21 vaccine will...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
bee77534-e763-5db8-bbbc-74e1e67ccccb
DOI
10.1101/2025.07.14.664425
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in <i>Plasmodium falciparum</i>DOI 10.1101/2025.07.14.664425
Unlocking the Global Antigenic Diversity and Balancing Selection of<i>Plasmodium falciparum</i>Semantic proximity
Diversity and selection analyses identify transmission-blocking antigens as the optimal vaccine candidates in<i>Plasmodium falciparum</i>Semantic proximity
Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens.Semantic proximity
Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigensSemantic proximity
Identification, Selection and Immune Assessment of Liver Stage CD8 T Cell Epitopes From Plasmodium falciparum.Semantic proximity
Immunoinformatics-Driven Design of Malaria Protein-Based Multi-Epitope VaccineSemantic proximity
Prioritization of SARS-CoV-2 epitopes using a pan-HLA and global population inference approachSemantic proximity
In silico study to predict promiscuous T cell and B cell-epitopes derived from the vaccine candidate antigens of Plasmodium vivax binding to MHC class-II alleles.Semantic proximity
Systematic Serological Diversity of a Putative Malaria Vaccine Candidate and Broad ProtectionSemantic proximity
Pf-PeptideFilter: An Interactive Catalogue of Peptide Vaccine Candidates for <i>Plasmodium falciparum</i>Semantic proximity
COMBO-RATE: An experimentally validated bioinformatic tool to identify promiscuous HLA restrictionsSemantic proximity
Protein interaction analysis of <i>Plasmodium falciparum</i> circumsporozoite protein variants with human immunoproteins explains RTS,S vaccine efficacy in GhanaSemantic proximity
Select a neighboring publication to make it the new centre.