Article
Modulating gene regulation function by chemically controlled transcription factor clustering.
Nature communications - 13 May 2022
Wu Jiegen, Chen Baoqiang, Liu Yadi, Ma Liang, Huang Wen, Lin Yihan
Abstract excerpt
Recent studies have suggested that transcriptional protein condensates (or clusters) may play key roles in gene regulation and cell fate determination. However, it remains largely unclear how the gene regulation function is quantitatively tuned by transcription factor (TF) clustering and whether TF clustering may confer emergent behaviors as in cell fate control systems. Here, to address this, we construct...
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