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Article

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.

PloS one - 1 Jan 2022

Shaheen Abida, Alam Syed Mahboob, Azam Fahad, Saleem Salman Ahmad, Khan Moosa, Hasan Syed Saud, Liaquat Afrose

Abstract excerpt

BACKGROUND AND OBJECTIVE: Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to...

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PMID: 35559956
DOI: 10.1371/journal.pone.0266559
PMCID: PMC9106170

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