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Article

Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.

Basic & clinical pharmacology & toxicology - 1 Mar 2019

Yamamoto Priscila A, Benzi Jhohann R L, Azeredo Francine J, Dach Fabíola, Ianhez Júnior Edgar, Zanelli Cleslei F, de Moraes Natália V

Abstract excerpt

Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic polymorphisms effect on GAB pharmacokinetic (PK) variability using a population pharmacokinetic approach. Data were collected from 53 patients with chronic pain receiving multiple doses of GAB....

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PMID: 30192429
DOI: 10.1111/bcpt.13126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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