Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of single nucleotide polymorphism of LAT1 on therapeutic response to gabapentinoids in Pakistani patients with neuropathic pain.

Basic & clinical pharmacology & toxicology - 1 Mar 2021

Shaheen Abida, Alam Syed Mahboob, Azam Fahad, Khan Moosa, Ahmad Saleem Salman, Liaquat Afrose, Mumtaz Sana

Abstract excerpt

Gabapentinoids are substrate of L-type amino acid transporter 1 (LAT1) for distribution across the blood-brain barrier. The present study aimed to evaluate the effect of LAT1 rs4240803 genetic polymorphism on the clinical efficacy and tolerability of gabapentinoids in Pakistani patients with neuropathic pain. Three-hundred and ninety-two patients were recruited, genotyped for SNP rs4240803, and followed up for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype
Share to Neuralgia
Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 33190395
DOI: 10.1111/bcpt.13534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of single nucleotide polymorphism of LAT1 on therapeutic response to gabapentinoids in Pakistani patients with neuropathic pain.PMID 33190395Read ↗

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.Semantic proximity Read ↗

Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.Semantic proximity Read ↗

Gabapentin’s Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic ProfilesSemantic proximity Read ↗

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations.Semantic proximity Read ↗

Trace amine associated receptor 1: Predicted effects of single nucleotide variants on structure-function in geographically diverse populationsSemantic proximity Read ↗

Trace amine associated receptor 1: Predicted effects of single nucleotide variants on structure-function in geographically diverse populationsSemantic proximity Read ↗

Mechanisms and implications in gene polymorphism mediated diverse reponses to sedatives, analgesics and muscle relaxantsSemantic proximity Read ↗

Prescribing of antiepileptic drugs for the treatment of painSemantic proximity Read ↗

OCT1 pharmacogenetics in pain management: is a clinical application within reach?Semantic proximity Read ↗

A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients.Semantic proximity Read ↗

Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.Semantic proximity Read ↗

Abcb1 Gene Polymorphisms Are Associated With Clinical Response to Nabiximols in Patients With Multiple Sclerosis-related SpasticitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.