Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.

Clinical pharmacology and therapeutics - 1 Mar 2008

Urban T J, Brown C, Castro R A, Shah N, Mercer R, Huang Y, Brett C M, Burchard E G, Giacomini K M

Abstract excerpt

Gabapentin is an anticonvulsant that is widely prescribed for epilepsy and other neuropathic disorders. The pharmacokinetics, particularly the absorption and renal elimination, of gabapentin appear to involve membrane transporters. In this study, we tested the hypothesis that organic cation trans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amines
Share to gamma-Aminobutyric Acid
Share to Glomerular Filtration Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules

Share to Leucine

Share to Metabolic Clearance Rate

Share to Organic Cation Transporter 1

Share to Phenylalanine

Source

Identifiers

PMID: 17609685
DOI: 10.1038/sj.clpt.6100271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17609685-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.PMID 17609685Read ↗

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4)Semantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.Semantic proximity Read ↗

Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.Semantic proximity Read ↗

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.Semantic proximity Read ↗

Genetic variation in organic cation transporters and considerations in drug development.Semantic proximity Read ↗

The human organic cation transporter OCT1 and its role as a target for drug responsesSemantic proximity Read ↗

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.Semantic proximity Read ↗

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.Semantic proximity Read ↗

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Semantic proximity Read ↗

Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.