Article

Gabapentin’s Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic Profiles

2024-12-10

Abstract excerpt

Neuropathic pain affects approximately 10% of the adult population and is commonly treated with gabapentin (GBP), a repurposed anticonvulsant drug. Despite its widespread clinical use, GBP’s efficacy varies significantly among patients, highlighting the need to better understand its functional and molecular impacts on human pain-sensing neurons. In this study, we characterized the electrophysiological and transcri...

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Literature Corpus work: c5a399a3-718c-5f66-b797-85e53d3ed293
DOI: 10.1101/2024.12.05.627067

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