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Article

Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts.

Microbiology spectrum - 29 Jun 2022

Ko Karrie K K, Yingtaweesittikul Hatairat, Tan Thuan Tong, Wijaya Limin, Cao Delphine Yanhong, Goh Sui Sin, Abdul Rahman Nurdyana Binte, Chan Kenneth X L, Tay Hui Ming, Sim James Heng Chiak, Chan Kian Sing, Oon Lynette L E, Nagarajan Niranjan, Suphavilai Chayaporn

Abstract excerpt

Immunocompromised hosts with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been implicated in the emergence of highly mutated SARS-CoV-2 variants. Spike mutations are of particular concern because the spike protein is a key target for vaccines and therapeutics for SARS-CoV-2. Here, we report the emergence of spike mutations in two immunocompromised patients with persistent...

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Identifiers

PMID: 35543562
DOI: 10.1128/spectrum.00791-22
PMCID: PMC9241677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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