Article
Higher Levels of SARS-CoV-2 Genetic Variation in Immunocompromised Patients: A Retrospective Case-Control Study.
The Journal of infectious diseases - 12 Apr 2024
Guilbaud Romane, Franco Yusti Anna-Maria, Leducq Valentin, Zafilaza Karen, Bridier-Nahmias Antoine, Todesco Eve, Soulie Cathia, Fauchois Antoine, Le Hingrat Quentin, Kramer Laura, Goulenok Tiphaine, Salpin Mathilde, Daugas Eric, Dorent Richard, Ottaviani Sébastien, Zalcman Gérard, Ghosn Jade, Choquet Sylvain, Cacoub Patrice, Amoura Zahir, Barroux Benoit, Pourcher Valérie, Spano Jean-Philippe, Louet Martine, Marcelin Anne-Geneviève, Calvez Vincent, Charpentier Charlotte, Descamps Diane, Marot Stéphane, Ferré Valentine Marie, Coppée Romain
Abstract excerpt
BACKGROUND: A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection lasts longer in immunocompromised hosts than in immunocompetent patients. Prolonged infection is associated with a higher probability of selection for novel SARS-CoV-2 mutations, particularly in the spike protein, a critical target for vaccines and therapeutics. METHODS: From December 2020 to September 2022, respiratory samples...
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