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Article

Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma.

Oncogene - 1 Jun 2022

Moser Russell, Gurley Kay E, Nikolova Olga, Qin Guangrong, Joshi Rashmi, Mendez Eduardo, Shmulevich Ilya, Ashley Amanda, Grandori Carla, Kemp Christopher J

Abstract excerpt

The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state. To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of syngeneic Ras mutant squamous cell carcinoma (SCC)...

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Share to Carcinoma, Squamous Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Share to ras Proteins

Share to RNA, Small Interfering

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 35538224
DOI: 10.1038/s41388-022-02330-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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