Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.

doi:10.1073/pnas.0907325106

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Article

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.

Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 2009

Sos Martin L, Fischer Stefanie, Ullrich Roland, Peifer Martin, Heuckmann Johannes M, Koker Mirjam, Heynck Stefanie, Stückrath Isabel, Weiss Jonathan, Fischer Florian, Michel Kathrin, Goel Aviva, Regales Lucia, Politi Katerina A, Perera Samanthi, Getlik Matthäus, Heukamp Lukas C, Ansén Sascha, Zander Thomas, Beroukhim Rameen, Kashkar Hamid, Shokat Kevan M, Sellers William R, Rauh Daniel, Orr Christine, Hoeflich Klaus P, Friedman Lori, Wong Kwok-Kin, Pao William, Thomas Roman K

Abstract excerpt

In cancer, genetically activated proto-oncogenes often induce "upstream" dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce massive apoptosis of tumor cells, leading to sometimes dramatic tumor regressions in patients. The PI3K and MAPK signaling pathways are central regulators of oncogenic transformation and tumor maintenance. We hypothesized...

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PMID: 19805051
DOI: 10.1073/pnas.0907325106
PMCID: PMC2757399

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