Article
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype.
Nature - 19 Jun 2008
McMurray Helene R, Sampson Erik R, Compitello George, Kinsey Conan, Newman Laurel, Smith Bradley, Chen Shaw-Ree, Klebanov Lev, Salzman Peter, Yakovlev Andrei, Land Hartmut
Abstract excerpt
Understanding the molecular underpinnings of cancer is of critical importance to the development of targeted intervention strategies. Identification of such targets, however, is notoriously difficult and unpredictable. Malignant cell transformation requires the cooperation of a few oncogenic mutations that cause substantial reorganization of many cell features and induce complex changes in gene expression...
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