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Article

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

Cell - 29 May 2009

Scholl Claudia, Fröhling Stefan, Dunn Ian F, Schinzel Anna C, Barbie David A, Kim So Young, Silver Serena J, Tamayo Pablo, Wadlow Raymond C, Ramaswamy Sridhar, Döhner Konstanze, Bullinger Lars, Sandy Peter, Boehm Jesse S, Root David E, Jacks Tyler, Hahn William C, Gilliland D Gary

Abstract excerpt

An alternative to therapeutic targeting of oncogenes is to perform "synthetic lethality" screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify synthetic lethal interactions in cancer cells harboring mutant KRAS, the most commonly mutated human oncogene. We find that cells that are dependent on mutant KRAS exhibit...

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Source

Identifiers

PMID: 19490892
DOI: 10.1016/j.cell.2009.03.017

Genes

KRAS
STK33
BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.PMID 19490892Read ↗

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SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers.Semantic proximity Read ↗

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.Semantic proximity Read ↗

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