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Article

Functional kinomics identifies candidate therapeutic targets in head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2014

Moser Russell, Xu Chang, Kao Michael, Annis James, Lerma Luisa Angelica, Schaupp Christopher M, Gurley Kay E, Jang In Sock, Biktasova Asel, Yarbrough Wendell G, Margolin Adam A, Grandori Carla, Kemp Christopher J, Méndez Eduardo

Abstract excerpt

PURPOSE: To identify novel therapeutic drug targets for p53-mutant head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN: RNAi kinome viability screens were performed on HNSCC cells, including autologous pairs from primary tumor and recurrent/metastatic lesions, and in parallel on murine squamous cell carcinoma (MSCC) cells derived from tumors of inbred mice bearing germline mutations in Trp53, and...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 25125259
DOI: 10.1158/1078-0432.CCR-13-2858
PMCID: PMC4135446

Genes

WEE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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