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Article

Synthetic lethality-based targets for discovery of new cancer therapeutics.

Cancer genomics & proteomics - 1 Jan 2000

Weidle Ulrich H, Maisel Daniela, Eick Dirk

Abstract excerpt

Synthetic lethality is based on the incompatibility of cell survival with the loss of function of two or more genes, not with loss of function of a single gene. If targets of synthetic lethality are deregulated or mutated in cancer cells, the strategy of synthetic lethality can result in significant increase of therapeutic efficacy and a favourable therapeutic window. In this review, we discuss synthetic...

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PMID: 21737609

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