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Challenges and Opportunities in Defining the Essential Cancer Kinome

24 Mar 2009

Abstract excerpt

Signaling pathways controlled by protein kinases underlie a large fraction of human diseases and participate in the development and progression of all forms of cancer. Targeted therapeutic strategies to treat cancer and other diseases are focused almost exclusively on protein kinases, with a strong bias toward a small subset of the entire human kinome. RNA interference (RNAi)-based screens for protein kinase...

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PMID: 19318621
DOI: 10.1126/scisignal.263pe15

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