Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment.

doi:10.1111/bjh.15461

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Article

Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment.

British journal of haematology - 1 Sept 2018

Stosch Juliane M, Heumüller Anezka, Niemöller Christoph, Bleul Sabine, Rothenberg-Thurley Maja, Riba Julian, Renz Nathalie, Szarc Vel Szic Katarzyna, Pfeifer Dietmar, Follo Marie, Pahl Heike L, Zimmermann Stefan, Duyster Justus, Wehrle Julius, Lübbert Michael, Metzeler Klaus H, Claus Rainer, Becker Heiko

Abstract excerpt

Knowledge of the molecular and clonal characteristics in the myelodysplastic syndromes (MDS) and during progression to acute myeloid leukaemia (AML) is essential to understand the disease dynamics and optimize treatment. Sequencing serial bone marrow samples of eight patients, we observed that MDS featured a median of 3 mutations. Mutations in genes involved in RNA-splicing or epigenetic regulation were most...

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PMID: 29974943
DOI: 10.1111/bjh.15461

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