Article
Clonal evolution in myelodysplastic syndromes.
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jun 2016
Yoshida Kenichi
Abstract excerpt
During the past ten years, genome-wide analysis of genetic alterations in myelodysplastic syndromes (MDS) has improved our understanding of their pathogenesis. Especially, single nucleotide polymorphism array karyotyping and next-generation sequencing technologies (NGS) have unveiled frequent genetic changes in novel functional pathways, including DNA methylation, RNA splicing and cohesin complex formation, in...
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