Article
The clonal origins of leukemic progression of myelodysplasia.
Leukemia - 1 Sept 2017
Kim T, Tyndel M S, Kim H J, Ahn J-S, Choi S H, Park H J, Kim Y-K, Yang D-H, Lee J-J, Jung S-H, Kim S Y, Min Y H, Cheong J-W, Sohn S K, Moon J H, Choi M, Lee M, Zhang Z, Kim D D H
Abstract excerpt
The genetics behind the progression of myelodysplasia to secondary acute myeloid leukemia (sAML) is poorly understood. In this study, we profiled somatic mutations and their dynamics using next generation sequencing on serial samples from a total of 124 patients, consisting of a 31 patient discovery cohort and 93 patients from two validation cohorts. Whole-exome analysis on the discovery cohort revealed that 29...
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