Clonal architecture of secondary acute myeloid leukemia.

doi:10.1056/NEJMoa1106968

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Article

Clonal architecture of secondary acute myeloid leukemia.

The New England journal of medicine - 22 Mar 2012

Walter Matthew J, Shen Dong, Ding Li, Shao Jin, Koboldt Daniel C, Chen Ken, Larson David E, McLellan Michael D, Dooling David, Abbott Rachel, Fulton Robert, Magrini Vincent, Schmidt Heather, Kalicki-Veizer Joelle, O'Laughlin Michelle, Fan Xian, Grillot Marcus, Witowski Sarah, Heath Sharon, Frater John L, Eades William, Tomasson Michael, Westervelt Peter, DiPersio John F, Link Daniel C, Mardis Elaine R, Ley Timothy J, Wilson Richard K, Graubert Timothy A

Abstract excerpt

BACKGROUND: The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to secondary AML are not well understood. METHODS: We performed whole-genome sequencing of seven paired samples of skin and bone marrow in seven subjects with secondary AML to identify somatic...

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Identifiers

PMID: 22417201
DOI: 10.1056/NEJMoa1106968
PMCID: PMC3320218

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