Y-Chromosome Gene, Uty , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines

Abstract excerpt

Abstract Rationale Idiopathic pulmonary arterial hypertension (PAH) is a terminal pulmonary vascular disease characterized by increased pressure, right ventricular failure, and death. PAH exhibits a striking sex bias and is up to four times more prevalent in females. Understanding the molecular basis behind sex differences could help uncover novel therapies. Objectives We previously discovered that the Y...

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