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Article

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2019

Eales James M, Maan Akhlaq A, Xu Xiaoguang, Michoel Tom, Hallast Pille, Batini Chiara, Zadik Daniel, Prestes Priscilla R, Molina Elsa, Denniff Matthew, Schroeder Juliane, Bjorkegren Johan L M, Thompson John, Maffia Pasquale, Guzik Tomasz J, Keavney Bernard, Jobling Mark A, Samani Nilesh J, Charchar Fadi J, Tomaszewski Maciej

Abstract excerpt

OBJECTIVE: The male-specific region of the Y chromosome (MSY) remains one of the most unexplored regions of the genome. We sought to examine how the genetic variants of the MSY influence male susceptibility to coronary artery disease (CAD) and atherosclerosis. Approach and Results: Analysis of 129 133 men from UK Biobank revealed that only one of 7 common MSY haplogroups (haplogroup I1) was associated with...

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Share to Chromosomes, Human, Y
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Identifiers

PMID: 31644355
DOI: 10.1161/ATVBAHA.119.312405
PMCID: PMC6818981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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