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Article

Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure.

Nature cardiovascular research - 1 Mar 2024

Horitani Keita, Chavkin Nicholas W, Arai Yohei, Wang Ying, Ogawa Hayato, Yura Yoshimitsu, Evans Megan A, Cochran Jesse D, Thel Mark C, Polizio Ariel H, Sano Miho, Miura-Yura Emiri, Arai Yuka, Doviak Heather, Arnold Arthur P, Gelfand Bradley D, Hirschi Karen K, Sano Soichi, Walsh Kenneth

Abstract excerpt

Heart failure affects millions of people worldwide, with men exhibiting a higher incidence than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in leukocytes is causally associated with an increased risk for heart failure. Here, we show that LOY macrophages from the failing hearts of humans with dilated cardiomyopathy exhibit widespread changes in gene expression that correlate with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39183958
DOI: 10.1038/s44161-024-00441-z
PMCID: PMC11343478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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