Article
Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.
Nature communications - 19 Jan 2016
Yamamoto Yusuke, Wang Xia, Bertrand Denis, Kern Florian, Zhang Ting, Duleba Marcin, Srivastava Supriya, Khor Chiea Chuen, Hu Yuanyu, Wilson Lane H, Blaszyk Hagen, Rolshud Daniil, Teh Ming, Liu Jianjun, Howitt Brooke E, Vincent Matthew, Crum Christopher P, Nagarajan Niranjan, Ho Khek Yu, McKeon Frank, Xian Wa
Abstract excerpt
The precancerous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett's, gastric and oesophageal epithelia that yield divergent tumour types following in vitro transformation and xenografting. Genomic analyses reveal a broad mutational spectrum...
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