Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

9 Apr 2016

Abstract excerpt

We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activity. Functionally, HPF1 promotes PARP-1-dependent in trans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Integrated Circuits and Semiconductor Failure Analysis
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27067600
DOI: 10.1016/j.molcel.2016.03.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation ActivityPMID 27067600Read ↗

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histonesSemantic proximity Read ↗

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.Semantic proximity Read ↗

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesionsSemantic proximity Read ↗

PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkersSemantic proximity Read ↗

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.Semantic proximity Read ↗

PARP1: Liaison of Chromatin Remodeling and TranscriptionSemantic proximity Read ↗

Transcriptional regulation mechanism of PARP1 and its application in disease treatmentSemantic proximity Read ↗

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Semantic proximity Read ↗

A Double-Edged Sword: The Two Faces of PARylationSemantic proximity Read ↗

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA RepairSemantic proximity Read ↗

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral DynamicsSemantic proximity Read ↗

Transcriptional Roles of PARP1 in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.