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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines.

Cell reports - 23 Jul 2024

Anagho Holda Awah, Mullari Meeli, Prósz Aurél György, Buch-Larsen Sara Charlotte, Cho Hayoung, Locard-Paulet Marie, Szallasi Zoltan, Nielsen Michael Lund

Abstract excerpt

ADP-ribosylation (ADPr) signaling plays a crucial role in DNA damage response. Inhibitors against the main enzyme catalyzing ADPr after DNA damage, poly(ADP-ribose) polymerase 1 (PARP1), are used to treat patients with breast cancer harboring BRCA1/2 mutations. However, resistance to PARP inhibitors (PARPi) is a major obstacle in treating patients. To understand the role of ADPr in PARPi sensitivity, we use...

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PMID: 38985679
DOI: 10.1016/j.celrep.2024.114433

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