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Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Biogerontology - 1 Aug 2022

Saul Nadine, Dhondt Ineke, Kuokkanen Mikko, Perola Markus, Verschuuren Clara, Wouters Brecht, von Chrzanowski Henrik, De Vos Winnok H, Temmerman Liesbet, Luyten Walter, Zečić Aleksandra, Loier Tim, Schmitz-Linneweber Christian, Braeckman Bart P

Abstract excerpt

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn's disease, malabsorption or kidney disease. Six single...

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Identifiers

PMID: 35748965
DOI: 10.1007/s10522-022-09969-8
PMCID: PMC9388463

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