Article
Adaptive capacity to bacterial diet modulates aging in C. elegans.
Cell metabolism - 4 Feb 2014
Pang Shanshan, Curran Sean P
Abstract excerpt
Diet has a substantial impact on cellular metabolism and physiology. Animals must sense different food sources and utilize distinct strategies to adapt to diverse diets. Here we show that Caenorhabditis elegans lifespan is regulated by their adaptive capacity to different diets, which is controlled by alh-6, a conserved proline metabolism gene. alh-6 mutants age prematurely when fed an Escherichia coli OP50 but...
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