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PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA

25 Apr 2022

Abstract excerpt

Hepatitis B virus infection remains a major health problem worldwide due to its high risk of liver failure and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA), which is present as an individual minichromosome, serves as the template for transcription of all viral RNAs and pla ays critical role in viral persistence. Therefore, there is an urgent need to gain broader insight into the transcription...

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PMID: 35468873
DOI: 10.1038/s41419-022-04852-3

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